Ruby on Rails is my preferred framework for the development of custom rich-internet applications.
Rails is ideal for new application development with fast, iterative development loops. Quickly integrate existing open-source projects and APIs to speed up development times.
Wordpress is an easy to use, lightweight CMS perfect for blogs and other content-heavy sites that do not require extensive customization. The extensive, existing library of plugins can keep down costs and speed development.
I have headed up the design and prototyping of several web applications over the past two years. Starting with user flow, I generate mockups before beginning the design process in Fireworks. I have also built prototype pages in HTML & JS that demonstrate the full interface before passing the design off to the engineering team.